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The researcher returned to find that cells had unexpectedly grown during this additional time period. They were surprised to find that further testing showed the deadly fungus had survived antifungal treatment by creating multiple versions of its own genome, thereby increasing its chances of mutating to evade the drug and survive.","spanStart":0,"spanEnd":164,"status":"unverified","notAutoChecked":null,"namedPersonAllegation":false,"checkableBand":"medium","demoted":false,"demotedReason":null,"l3Attempted":true,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:25:30.053Z","evidence":[],"history":[{"id":"01M4W6EF9QD9TMAB9B82P701MW","claimId":"01M4W6E2BZXJ5F6VRXQ3013SMV","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:11.819Z"}],"corrections":[],"editorial":[],"endorsements":[]},{"id":"01M4W6E2BZXJ5F6VRXQ3013SMW","receiptId":"01M4W6CJPFESFHGP7MKW4C4PPH","ord":20,"text":"The researcher returned to find that cells had unexpectedly grown during this additional time period.","sourceText":"The researcher returned to find that cells had unexpectedly grown during this additional time period.","derivedFrom":"span","context":"The research team was initially testing for drug resistance when a researcher accidentally left plates of cells incubating for longer than the required test period. The researcher returned to find that cells had unexpectedly grown during this additional time period. 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The researcher returned to find that cells had unexpectedly grown during this additional time period. 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We were surprised to discover an entirely new mechanism for this fungus to survive—particularly with luck playing a big part in the discovery.","spanStart":0,"spanEnd":322,"status":"unverified","notAutoChecked":"private_party","namedPersonAllegation":false,"checkableBand":"medium","demoted":false,"demotedReason":null,"l3Attempted":false,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:18:29.123Z","evidence":[],"history":[{"id":"01M4W6EHVK1XT76Z77SWSJXXGH","claimId":"01M4W6E2BZXJ5F6VRXQ3013SMY","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:14.444Z"}],"corrections":[],"editorial":[],"endorsements":[]},{"id":"01M4W6E2BZXJ5F6VRXQ3013SMZ","receiptId":"01M4W6CJPFESFHGP7MKW4C4PPH","ord":23,"text":"We were surprised to discover an entirely new mechanism for this fungus to survive—particularly with luck playing a big part in the discovery.","sourceText":"We were surprised to discover an entirely new mechanism for this fungus to survive—particularly with luck playing a big part in the discovery.","derivedFrom":"span","context":"Dr. Sarah Murphy, former postdoctoral researcher at City St George's University of London and co-first author, said, \"We initially set out to investigate why antifungal drugs weren't working to kill Candida auris, despite laboratory tests showing that they were not resistant and that the drugs should have been effective. 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Our discovery means we need to now look at new ways of treating people and eradicating this deadly fungus from hospitals.\"","spanStart":76,"spanEnd":190,"status":"unverified","notAutoChecked":null,"namedPersonAllegation":false,"checkableBand":"medium","demoted":false,"demotedReason":null,"l3Attempted":true,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:25:25.285Z","evidence":[],"history":[{"id":"01M4W6EKJ8Z0DNTY4JMM75F8CD","claimId":"01M4W6E2BZXJ5F6VRXQ3013SN0","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:16.186Z"}],"corrections":[],"editorial":[],"endorsements":[]},{"id":"01M4W6E2BZXJ5F6VRXQ3013SN1","receiptId":"01M4W6CJPFESFHGP7MKW4C4PPH","ord":25,"text":"First, we did not identify any of the DNA mutations that we might have expected.","sourceText":"First, we did not identify any of the DNA mutations that we might have expected.","derivedFrom":"span","context":"Expanding further on the finding, Gifford said, \"This study had a number of surprising elements. 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This is a trick that other fungi have used in the past, but not one that is well known in C. auris. In fact, there were two populations, some growing slowly, others growing more rapidly. We call it 'bet-hedging' when a bug uses multiple tactics to increase its chances of developing resistance and evading treatment.\"","spanStart":0,"spanEnd":96,"status":"unverified","notAutoChecked":null,"namedPersonAllegation":false,"checkableBand":"medium","demoted":false,"demotedReason":null,"l3Attempted":true,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:25:23.155Z","evidence":[],"history":[{"id":"01M4W6EP4GRN8CM53ATX59KWSD","claimId":"01M4W6E2BZXJ5F6VRXQ3013SN3","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:18.822Z"}],"corrections":[],"editorial":[],"endorsements":[]},{"id":"01M4W6E2BZXJ5F6VRXQ3013SN4","receiptId":"01M4W6CJPFESFHGP7MKW4C4PPH","ord":28,"text":"This is a trick that other fungi have used in the past, but not one that is well known in C. auris.","sourceText":"This is a trick that other fungi have used in the past, but not one that is well known in C. auris.","derivedFrom":"span","context":"\"We were surprised to find that surviving cells had made multiple copies of their entire genome. This is a trick that other fungi have used in the past, but not one that is well known in C. auris. In fact, there were two populations, some growing slowly, others growing more rapidly. We call it 'bet-hedging' when a bug uses multiple tactics to increase its chances of developing resistance and evading treatment.\"","spanStart":97,"spanEnd":196,"status":"unverified","notAutoChecked":null,"namedPersonAllegation":false,"checkableBand":"medium","demoted":false,"demotedReason":null,"l3Attempted":true,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:25:27.945Z","evidence":[],"history":[{"id":"01M4W6EPZW80SQPY6ZTHXPA2YH","claimId":"01M4W6E2BZXJ5F6VRXQ3013SN4","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:19.697Z"}],"corrections":[],"editorial":[],"endorsements":[]},{"id":"01M4W6E2BZXJ5F6VRXQ3013SN5","receiptId":"01M4W6CJPFESFHGP7MKW4C4PPH","ord":29,"text":"In fact, there were two populations, some growing slowly, others growing more rapidly.","sourceText":"In fact, there were two populations, some growing slowly, others growing more rapidly.","derivedFrom":"span","context":"\"We were surprised to find that surviving cells had made multiple copies of their entire genome. This is a trick that other fungi have used in the past, but not one that is well known in C. auris. In fact, there were two populations, some growing slowly, others growing more rapidly. 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Further tests confirmed the rapid growth of CRZ1 mutants and that their cell walls appeared to be unaffected by antifungal drugs.","spanStart":0,"spanEnd":211,"status":"unverified","notAutoChecked":null,"namedPersonAllegation":false,"checkableBand":"high","demoted":false,"demotedReason":null,"l3Attempted":true,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:25:28.984Z","evidence":[],"history":[{"id":"01M4W6ERPF71RWJF46DNY6RX3R","claimId":"01M4W6E2BZXJ5F6VRXQ3013SN6","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:21.446Z"}],"corrections":[],"editorial":[],"endorsements":[]},{"id":"01M4W6E2BZXJ5F6VRXQ3013SN7","receiptId":"01M4W6CJPFESFHGP7MKW4C4PPH","ord":31,"text":"Further tests confirmed the rapid growth of CRZ1 mutants and that their cell walls appeared to be unaffected by antifungal drugs.","sourceText":"Further tests confirmed the rapid growth of CRZ1 mutants and that their cell walls appeared to be unaffected by antifungal drugs.","derivedFrom":"span","context":"The team found that the more rapidly growing cells contained a wide range of mutations in a gene that has been studied in other organisms for its role in governing cell wall synthesis, called \"Crazy-one\" (CRZ1). Further tests confirmed the rapid growth of CRZ1 mutants and that their cell walls appeared to be unaffected by antifungal drugs.","spanStart":212,"spanEnd":341,"status":"unverified","notAutoChecked":null,"namedPersonAllegation":false,"checkableBand":"medium","demoted":false,"demotedReason":null,"l3Attempted":true,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:25:29.524Z","evidence":[],"history":[{"id":"01M4W6ESHXHYDJ08594JE4J6WH","claimId":"01M4W6E2BZXJ5F6VRXQ3013SN7","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:22.318Z"}],"corrections":[],"editorial":[],"endorsements":[]},{"id":"01M4W6E2BZXJ5F6VRXQ3013SN8","receiptId":"01M4W6CJPFESFHGP7MKW4C4PPH","ord":32,"text":"Combining treatments to counter fungal adaptation","sourceText":"Combining treatments to counter fungal adaptation","derivedFrom":"span","context":"Combining treatments to counter fungal adaptation","spanStart":0,"spanEnd":49,"status":"unverified","notAutoChecked":null,"namedPersonAllegation":false,"checkableBand":"medium","demoted":true,"demotedReason":"not_checkable","l3Attempted":false,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:19:10.300Z","evidence":[],"history":[{"id":"01M4W6ETD6092ZJ9TGFR6Z9XPD","claimId":"01M4W6E2BZXJ5F6VRXQ3013SN8","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:23.193Z"}],"corrections":[],"editorial":[],"endorsements":[]},{"id":"01M4W6E2BZXJ5F6VRXQ3013SN9","receiptId":"01M4W6CJPFESFHGP7MKW4C4PPH","ord":33,"text":"Researchers are now looking at options including the use of antifungal drugs in combination, which is being addressed via the Exeter-led UKRI-funded Fungi-CARE program, also in partnership with colleagues at City St George's.","sourceText":"Researchers are now looking at options including the use of antifungal drugs in combination, which is being addressed via the Exeter-led UKRI-funded Fungi-CARE program, also in partnership with colleagues at City St George's.","derivedFrom":"span","context":"Researchers are now looking at options including the use of antifungal drugs in combination, which is being addressed via the Exeter-led UKRI-funded Fungi-CARE program, also in partnership with colleagues at City St George's.","spanStart":0,"spanEnd":225,"status":"unverified","notAutoChecked":null,"namedPersonAllegation":false,"checkableBand":"high","demoted":false,"demotedReason":null,"l3Attempted":true,"createdAt":"2026-10-14T03:13:58.743Z","updatedAt":"2026-10-14T03:25:31.092Z","evidence":[],"history":[{"id":"01M4W6EV8JTZGG7YY0RTZFSF1W","claimId":"01M4W6E2BZXJ5F6VRXQ3013SN9","fromStatus":null,"toStatus":"unverified","reason":"initial","actorType":"system","createdAt":"2026-10-14T03:14:24.068Z"}],"corrections":[],"editorial":[],"endorsements":[]}]},"comments":[]}